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Toxicologic Pathology
Instructions to Authors

Manuscript Submission

All manuscripts should be submitted electronically via Manuscript Central. Manuscript Central is located at Toxicologic Pathology Manuscript Central allows for rapid and easy submission of original and revised manuscripts, as well as reviewing and internal communication between authors, editors and reviewers via a web-based platform.

General Information
Guidelines: Manuscript Preparation
Conflict of Interest Guidelines
Copyright Form
Contact the Toxicologic Pathology Editorial Office

Getting Started
To submit a manuscript, please follow the instructions below:

  1. Launch your web browser (Internet Explorer 5 or higher or Netscape 6 or higher) and go to the Toxicologic Pathology’s Manuscript Central homepage (
  2. Log-in or click the “Create Account” option if you are a first-time user of Manuscript Central.
  3. If you are creating a new account:

    • After clicking on “Create Account” enter your name and e-mail information and click “Next”. Your e-mail information is very important.
    • Enter your institution and address information as prompted then click “Next.”
    • Enter a user ID and password of your choice (we recommend using your email address as your user ID) and then select your area of expertise. Click “Finish” when done.

  4. Log-in and select “Author Center.”
  5. Submitting Your Manuscript

  6. After you have logged in, click the “Submit a Manuscript” link in the menu bar.
  7. Enter data and answer questions as prompted
  8. Click on the “Next” button on each screen to save your work and advance to the next screen.
  9. You will be prompted to upload your files:

    • Click on the “Browse” button and locate the file on your computer.
    • Select the description of the file in the drop down next to the Browse button.
    • When you have selected all files you wish to upload, click the “Upload” button.
      • a. NOTE: you have a limit of 488 MB combined for all files you upload.

  10. Review your submission (in both PDF and HTML formats) before sending to the Editors. Click the “Submit” button when you are done reviewing.

You may stop a submission at any phase and save it to submit later. After submission, you will receive a confirmation via e-mail. You can also log-on to Manuscript Central any time to check the status of your manuscript. You will receive an e-mail once a decision has been made on your manuscript.

General Information

Toxicologic Pathology, the official journal of the Society of Toxicologic Pathology, will publish Original Research Articles, Symposium Articles, Review Articles, Meeting Reports, New Techniques, and Position Papers that are relevant to toxicologic pathology. Relevant topics include reports on safety assessment of pharmaceuticals, chemicals, food additives, pesticides, environmentally relevant chemicals, and medical devices; risk characterization of xenobiotics; investigative studies that contribute to refinement of the safety assessment process; mechanistic studies that provide a basis for interpreting and predicting toxicologic outcome; emerging approaches and methods in toxicologic pathology; spontaneous diseases that may influence toxicology studies, and animal and alternative models relevant to toxicologic pathology. Reviews may be contributed or invited.

A cover letter should indicate clearly that the work being submitted for publication constitutes original research and that it has not been published and is not under consideration for publication elsewhere.

Manuscript Preparation

Manuscripts are to be submitted to Toxicologic Pathology via Toxicologic Pathology Manuscript Central (

Submission of an article to Toxicologic Pathology assumes that 1) All authors have made a significant contribution to the article and share the responsibility of the manuscript content and findings. 2) All authors have read and approved the original and any revised version of the article that is submitted. 3) The manuscript has not been previously published and is not under consideration elsewhere. 4) Potential conflict of interest has been disclosed to the Associate Editor (see conflict of interest guidelines).

Original Research Articles submitted will contain:

A Cover letter saved in Microsoft Word format (.doc) or rich text format (.rtf) maybe uploaded to Toxicologic Pathology Manuscript Central.

Manuscripts should be double-spaced throughout (including references, footnotes, tables, and figure legends). Original research articles should be organized into sections as follows:

The Title Page should contain the title of the paper, the full names (first name, middle initial, last name) of all authors and the institution(s) where they reside. Changes of address since completion of the work can be included as footnotes.

The Running Title Page should contain a 35-character short title to be used as a running head; in a second line include the last name of the first author followed by “et al.” for multiple authored articles. At the bottom of the page, type the full name, address, phone number, and e-mail address of the author who will receive correspondence and proofs.

The Keywords Page facilitates indexing and retrieval services. The system will require you to enter a minimum of 3 and a maximum of 7 keywords.

The Abstract should be one paragraph consisting of a 150 to 200 word concise description of the objectives, methods, findings, and significance of the research.

The Introduction should contain brief background information and a clear statement of purpose and significance of the research being reported.

The Materials and Methods should provide a brief description of the methods and experiments and experimental design used. Methods and techniques that are well established should be referenced only. The description of the methods followed should allow reproducibility by other investigators. In reports covering in vivo experimentation, a description of the anesthesia or other procedures to avoid unnecessary pain or suffering should be included. Authors must state their compliance regarding rights of subjects in human experimentation or humane treatment and care of animals in research.

Research Involving Animals:
When studies involve the use of experimental animals, manuscripts should briefly describe the procedures employed for animal care and handling. Experiments that involve the use of animals must be conducted in accordance with institutional and governmental guiding principles in the use of animals.

Research Involving Human Subjects:
Studies involving research on human subjects must be approved by an appropriate Institutional Review Board (IRB) and comply with all relevant federal, state and local regulations. For research conducted outside federal regulations, authors must provide documentation that the research was conducted according to the principles of the Declaration of Helsinki ( A statement describing IRB approval, consent procedures and that all human participants gave written informed consent must appear at the beginning of the Methods section; the Editor-in-Chief may request to see such documentation.

Results should be concerned exclusively with the experimental design described in Methods and be presented as concisely as possible. Tables and figures should illustrate important points.

Discussion should concentrate on the discussion of the findings presented and, in context with other relevant published work, include the major points that add to the significance of the work. Extensive literature reviews or highly speculative discussion are discouraged.

Acknowledgments should be confined to those who contributed to the final presentation not in the role of author. Acknowledgment of technical contributions should be specific for participation, avoiding lengthy recognition that could have been made by other means.

Footnotes should be used sparingly, indicated by Arabic numerals superscripted to the authors, text, or titles. Footnotes should be typed sequentially on a separate page and can include disclaimers, the source of grant support, and address for offprint requests.

References. Pertinent literature references should be cited in the text in regular font within parentheses by author and year, e.g., (Smith, 1989; Jones et al., 2001). In the Reference list at the end of the paper, literature should be listed alphabetically by first author. Include the names and initials of all the authors, year of publication between parentheses, full title of paper, reference source abbreviated (use those listed in the Index Medicus), volume, and first and last page. Authors using EndNote may obtain the style file at The following are examples of reference listings:

Benedetti, S., Pirola, B., Pollo, B., Magrassi, L., Bruzzone, M. G., Rigamonti, D., Galli, R., Selleri, S., Di Meco, F., De Fraja, C., Vescovi, A., Cattaneo, E., and Finocchiaro, G. (2000). Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 6, 447-50.

Bos, J., and van Kreijl, C. (1992). Genes and gene products that regulate proliferation and differentiation: critical targets in carcinogenesis. In Mechanisms of Carcinogenesis in Risk Identification (H. Vainio, P. Magee, D. McGregor and A. McMichael, eds.), Vol. 116, pp. 57-65. IARC Scientific Publications, Lyon, France.

National Research Council (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC.

National Toxicology Program (1996). Toxicology and Carcinogenesis Studies of 1-Amino-2,4-dibromoanthraquinone (CAS No. 81-49-2) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 383, NIH Publication No. 96-2838., NIEHS, Research Triangle Park, NC.

Smith, B. R. (2000). Magnetic resonance imaging analysis of embryos. Methods Mol Biol 135, 211-6.

US Environmental Protection Agency (1981). Hazardous waste regulations, 40CFR Part 261., US Government Printing Office. Washington, DC.

Referencing of electronic documents on government, university program or department website

Chou. L., McClintock, R., Moretti, F. (1993). Technology and education: New wine in bottles: Choosing pasts and imagining educational futures. Retrieved August 24, 2000, from Columbia University, Institute for Learning Technologies Web site:

If a document is contained within a large and complex Web site (such as a government agency) identify the host organization and the relevant program or department before giving the URL for the document itself. Precede the URL with a colon.

Stand-alone document, no author identified, no date

GVU’s 8th WWW user survey. (n.d.). Retrieved August 8, 2000, from

For more information on citations for electronic text, please visit

The authors are responsible for the accuracy of the references quoted.

Tables should be submitted as separate files (not embedded in the text of the main document). Table should be double-spaced, numbered consecutively with Arabic numerals (1,2,3, etc.) and referred to in the text. Every table should have a title and each column should have a heading. Table footnotes should be in the form of lowercase superscript characters, listed alphabetically below the last table line. Material included in tables should not be duplicated by figures, or vice versa.

Animal Strain or Stock Designations. Designations for mouse and rat strains and stocks should conform to the Guidelines for Nomenclature of Mouse and Rat Strains ( from the International Committee on Standardized Genetic Nomenclature for Mice. You can also contact your animal supplier for this information. Other useful sites are the rat genome database ( and the Jackson Laboratory (

Abbreviations, Chemical Designations. The metric system is the standard for all measurement and variable notations. Abbreviations should be defined between parentheses when first indicated in the text. Italic text should be underlined and Chemical Abstracts or associated indexes should be used for conventional chemical designation. Authors may use, without definition, the following abbreviations:

M meter L Liter min minutes im intramuscular
Cm centimeter ml milliliter sec seconds ip intraperitoneal
Cm2 square centimeter µl microliter hr hours iv intravenous
Mm millimeter g Gram mo months po oral
µm micrometer kg kilogram yr years sc subcutaneous
Nm nanometer mg milligram     ic intracutaneous
µg microgram mM millimolar        
i.e. that is vs. versus Fig. Figure    
e.g. for example et al. and others        

Please refer to the Instructions For Figures for details on preparing your figures for submission. All figures must be submitted according to the Instructions for Figures (Instructions for Figures.docx). Questions regarding preparation of figures should be addressed to our Managing Editor, Stephanie Dickinson, at (856-223-9444) or

Figure Legends
Figure legends may be uploaded to Manuscript Central when the figures are uploaded, but they should always be included at the end of the manuscript. Figure legends should be complete and allow the reader to understand the figure without reading the text. Stains used or special techniques should be indicated. Scale bars and magnifications are not required and not preferred due to common inacurracies.

Image Magnifications
In the figure legend, only state “original objective used” as either 2X, 4X, 10X, 20X, 40X, 60X, etc. There should be no calculations for camera adapter lens, camera eyepiece lens, alteration of a photomicrograph with computer software, etc. If cell or object size needs to be accurate, then a scale bar may be used with an indication of micron size in the legend.

Brief Communications
These succinct manuscripts should have the same structure as full-length Original Research Articles but in much shorter form. Such brief reports will be prepared using the same formatting instructions as Original Research Articles, except that section headings will be used only for the Abstract, Acknowledgements, and References.

Brief Communications may describe any topic relevant to the practice of toxicologic pathology that does not warrant a full-length paper. In general, acceptable subjects will be suitable for presentation as Diagnostic Reports, or Special Reports. Diagnostic Reports will present a clinical, gross, and/or histopathologic abnormality followed by expository text defining the morphologic and etiologic diagnoses. Special Reports will describe scientific activities of STP or affiliated societies.

Brief Communications should not exceed three printed pages (usually six manuscript pages), including illustrations, tables, and references. Abstracts for Brief Communications should not exceed 150 words and the number of citations should be limited to 15.

Letters to the Editor/Book Reviews/Other Manuscript Types
Sample copies of Letters to the Editor and Books Reviews can be found on the Instructions and Forms Page of Manuscript Central. Information on preparing other manuscript types should be directed to the Editor-in-Chief or the Managing Editor at the Editorial Office.

Supplemental Material

  • Toxicologic Pathology accepts the following supplemental files Files to aid the reviewer and not for publication.
  • Files for publication in the online version of the manuscript.

Appropriate items for publication as supplemental material include; multimedia (e.g., movie files, audio files, 3D rendering files), illustrations, data tables, and text (e.g., appendices) that are too lengthy or of too limited interest for inclusion in the article. Links (URLs) in the online (printed) journal article allow users to navigate directly to the associated files.

All supplemental material must be approved by the Journal Editor as part of a manuscript’s normal review cycle, and must be listed in the reference section as follows: “See supplementary material at [URL will be inserted by SAGE] for [give brief description of material].”

Supplemental figures can be included in the online version of published mansucripts. Figures will be held to the same standards used to judge the main manuscript figures, and so should be subbited in accorrdance with the Instrucitons for Figures. The size and resolution of supplement figures may be reduced by the publisher for easier online access for readers.

Multimedia files can be included in the online version of published papers. Please adhere to the following guidelines when preparing multimedia files for submission:

  • When incorporating multimedia, note that the paper should be written so that the print version can be understood on its own.
  • Submit all multimedia files initially with the manuscript.
  • Treat all multimedia files as figures, numbered in sequence as they are referred to in text. (Multimedia files will not have a numbering scheme separate from the figures.)
  • All multimedia files must be cited in the text, referred to by their figure number.
  • For each multimedia file, provide a figure, which is a static representation of the multimedia file. Also provide an accompanying caption. At the end of the caption, include the phrase, “(enhanced online).”

Microarray Data
Toxicologic Pathology supports the efforts of databases that aggregate published data for the use of the scientific community. Therefore, before publication, large data sets (including microarray data, protein or DNA sequences, and atomic coordinates or electron microscopy maps for macromolecular structures) must be deposited in an approved database and an accession number provided for inclusion in the published paper. Data should be presented in MIAME-compliant standard format. Approved databases are Gene Expression Omnibus and ArrayExpress.

Large data sets with no appropriate approved repository must be housed as supporting online material at Toxicologic Pathology (SAGE publishing) or when this is not possible on the author’s website, provided a copy of the data is held in escrow at Toxicologic Pathology to ensure availability to readers. For answers to questions regarding allowable supporting online material, please see our guidelines: further questions can be directed to the Managing Editor, Stephanie Dickinson at the Editorial Office.

Acceptance Criteria
Every article submitted will be independently reviewed by at least two referees. Authors may suggest the names and addresses of up to five experts who could serve as referees. Authors may also suggest names of reviewers who may not be appropriate to review the manuscript. However, selection of referees is at the discretion of the Editor. Decisions concerning acceptance or rejection of manuscripts are the responsibility of the Editor.

After review and upon acceptance or provisional acceptance, specific details regarding submission of a final version will be provided.

Online Proofs
Authors will receive information to access electronic page proofs shortly prior to publication. Proofs should be carefully checked against the original manuscript for typographical errors and returned within the time frame stipulated. Only essential changes can be made at this stage. New information germane to the paper and considered essential can be added as Notes Added in Proof.

Associated Costs for Authors
Manuscript Fees.
In order to offset increasing publication costs, the Society has established a standard charge of $250.00 for each accepted manuscript. Payment should be made to Sage Publications by major credit card at the time of manuscript acceptance through Manuscript Central.

Color Figure Charges. Authors who wish to include color reproduction are encouraged to do so. There is no charge to authors for color images produced in the journal; however, we ask that authors only provide color artwork that is necessary and appropriate. Our referees will be asked to ensure that only those figures deemed absolutely necessary for the clarity of the manuscript will be allowed and any surplus to requirements will be removed.

Assistance with Color Artwork. Authors who require additional assistance with the preparation of color artwork, may contact our Illustrations Editor Beth Mahler at ( Authors may be charged additional fees for any artwork requiring extensive adjustment.

Abstracting Service
Articles published in Toxicologic Pathology are abstracted into the following search retrieval publications: Chemical Abstracts, Excerpta, Medica, Biological Abstracts, and Referativnyk Zhurnal and listed in Index Medicus, Current Contents, ISI/Biomed, and Science Citation Index.

Upon acceptance of an article, author(s) will be required to assign copyright ownership in writing to the Society of Toxicologic Pathology. Permission needs to be obtained for the use of borrowed material. Verbatim quotations, illustrations, tables, and photographs must be fully credited as to the original author and source. Permission requests for the use of material from Toxicologic Pathology should be made to the Editorial Office.

Journal Contact Information
Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP
National Institute of Environmental Health Sciences
Laboratory of Experimental Pathology
111 Alexander Drive
Research Triangle Park, NC 27709
Phone: 919-541-3474
Fax: 919-541-7666

Beth Mahler
Illustrations Editor
Experimental Pathology Laboratories

Stephanie Dickinson, CAE
Managing & Production Editor
Toxicologic Pathology Editorial Office
116 White Owl Trail
Mullica Hill, NJ 08062
(856) 223-9444 (phone/fax)