Times are subject to change

| Monday | Tuesday | Wednesday | Thursday |

Dr. Olga Pulido
Dr. Robert H. Garman
Dr. Michael Aschner
Dr. John W. Olney

Keynote Address: Alveolar Tissue Genesis: Trials and Tribulations

Dr. William Martin, II, M.D., Associate Director NIEHS, Director, Office of Translational Research, will give the keynote address. His talk is entitled, "Alveolar Tissue Genesis: Trials and Tribulations." Dr. Martin received his M.D. from the University of Minnesota in 1974, and completed his pulmonary and critical care training at Mayo Clinic in 1979. Following completion of his research training in the Pulmonary Branch at the National Heart, Lung and Blood Institute, he joined the staff of Mayo Clinic as a clinician-investigator in 1981. While on faculty at Indiana University, Dr. Martin served as a Health Policy Fellow, United States Senate, Labor and Human Resources Committee in 1995. Dr. Martin has served as the Dean of the University Of Cincinnati College Of Medicine and is a past president of the American Thoracic Society. He also served as the Director of Pulmonary and Critical Care at Indiana University for twelve years before becoming the Executive Associate Dean for Clinical Affairs at the University's School of Medicine.

Session I: The Science of Inhalation Studies
(Co-Chairs: Jack Harkema, DVM, PhD, DACVP, Michigan State University, East Lansing, MI and Kristen Nikula, DVM, PhD, DACVP, Pfizer Inc., Chesterfield, MO)

This first session will provide an overview of inhalation toxicology and respiratory toxicological pathology. The design and operation of inhalation exposure systems, the unique methods used to expose animals to inhaled xenobiotics , and the toxicity of inhaled nanoparticles will be presented.

Session II: Toxicology of Inhalation Studies
(Co-Chairs: Jack Harkema, DVM, PhD, DACVP, Michigan State University, East Lansing, MI and Kristen Nikula, DVM, PhD, DACVP, Pfizer Inc., Chesterfield, MO)

In this session, inhalation studies of urban atmospheres as well as efficacy and safety studies for therapeutic aerosols will be presented . There will be discussion of biochemical mechanisms commonly involved in respiratory disease. The session will conclude with a presentation on the integration of pathology and dosimetry in inhalation toxicology.

Session III: Methodologies for Respiratory System Studies (Chair: Robert Maronpot, DVM, DACVP, NIEHS, Research Triangle Park, NC)

Sophisticated and quantitative analyses of lung changes such as morphometry and stereology augment histopathology in the study of respiratory disease. Non-terminal evaluation of lung changes by magnetic resonance imaging and special imaging protocols can allow for time-course studies on individual animals. These topics, as well as a presentation on the molecular pathology of rodent lung tumors, will be covered in session III.

Laurence Hedlund, PhD, Duke University Medical Center, Durham, NC
Kennita Johnson, DVM, PhD, NIEHS/ NIH, Research Triangle Park, NC

Session IV: Current Concepts in Pulmonary Disease (Chair: Tom March, DVM, PhD, DACVP, Lovelace Respiratory Research Institute, Albuquerque, NM)

This session will summarize much of the latest thinking about the diagnostics and pathophysiology of several important pulmonary diseases. Speakers will give an appreciation of how respiratory disease might be induced or exacerbated by environmental influences, particularly by inhaled agents. Clinical management, including prospects of inhalation therapy (pharmaceuticals, biologicals), may be discussed. The final presentation in this session will be on comparative pathology of pulmonary neoplasia and diagnostic methodologies in tumor identification.

Session V: Environmental Respiratory Disease
(Co-Chairs: Dave Malarkey, DVM, PhD, DACVP, NIEHS, research Triangle Park, NC and Ann Hubbs, DVM, PhD, DACVP, NIOSH, Morgantown, WV)

This session will cover the causes, pulmonary responses, pathology, and basic science of environmental respiratory disease. Effects of chronic air pollution in urban and rural settings, emerging occupational lung diseases, and disorders caused by inhaled pollutants will be discussed.

Session VI: Pathology of the Respiratory Tract
(Chair: Roger Renne, DVM, DACVP, Battelle Toxicology Northwest, Richland, WA)

Session VI will begin with a review of the comparative anatomy of the respiratory system of laboratory animals and humans. A summary of inhalation studies performed by the National Toxicology Program will follow. The rodent nose and larynx will be discussed including anatomy, physiology, and pathology. This session will close with examples of respiratory tract lesions occurring in non-inhalation studies.