STP 34th Annual Symposium
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Pre- and Post-Meeting Workshops

Pre-Meeting Workshops

Post-Meeting Workshops

 

STP Pre-Meeting CE Course 1


(Registration required)

Saturday, October 17
8:00 AM-12:00 Noon

All Eyes Focused on Ocular Toxicology and Pathology

Co-Chairs: Brian J. Christian, PhD, DABT, Covance, Inc., Madison, WI; and Margarita M. Gruebbel, DVM, PhD, DACVP, EPL, Inc., Research Triangle Park, NC

The eye is often a target organ in toxicology studies. In order to determine the toxicological significance of effects in the eye, it is important to understand the basic structure and function of ocular tissues. Designing protocols for ocular toxicology studies also requires knowledge of species differences among the common testing laboratories as well as current methods for evaluation of ocular structures and functions. This session includes detailed reviews of anterior and posterior segments of the eye of common laboratory species; different tools used to determine treatment-related effects in ocular structures; and spontaneous and induced changes observed in each segment of the eye.

Comparative Anatomy and Histology of the Eye of Laboratory Animals
Margarita M. Gruebbel, DVM, PhD, DACVP, EPL, Inc., Research Triangle Park, NC

Evaluation of the Cornea and Lens
Robert J. Munger, DVM, DACVO, Animal Ophthalmology Clinic, Ltd., Dallas, TX

Evaluation of the Anterior and Posterior Chambers and Iridocorneal Angle
Leandro Teixeira, DVM, MSc, DACVP, University of Wisconsin-Madison, Madison, WI

Examination and Evaluation of the Posterior Segment–Retina
Steven D. Sorden, DVM, PhD, DACVP, Covance Laboratories, Inc., Madison, WI

 

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ACVP Primate Pathology Pre-Meeting Workshop


(Registration required)

Saturday, October 17
8:00 AM-5:00 PM

Non-human Primate Genetics and Geography: Impact on Study Design, Interpretation, and Results

Chair: Vito Sasseville, DVM, PhD, DACVP, Novartis Institutes for Biomedical Research, Cambridge, MA

Registrants will receive online access to all case presentation materials, including clinical history and scanned slide images, prior to the meeting.

Welcome and Program Overview
Vito Sasseville, DVM, PhD, DACVP, Novartis Institutes for Biomedical Research, Cambridge, MA

DNA–based Ancestry Determination of Rhesus (Macaca mulatta) and Cynomolgus Macaques (M. fascicularis)
Sree Kanthaswamy, BS(HONS), MPhil, PhD, Arizona State University, Glendale, AZ

Cynomolgus Monkey Origin: Clinical Pathology and Immunotoxicology Considerations
Nancy E. Everds, DVM, DACVP, Amgen, Inc., South San Francisco, CA

Retrospective Program Analysis
Karyn Colman, BVetMed, MRCVS, Novartis Institutes for Biomedical Research, East Hanover, NJ

Comparison of Background Histopatholgy Findings in Asian and Mauritius Cynomolgus Macaques
Jagannatha Mysore, MVSc, PhD, DACVP, Bristol-Myers Squibb, New Brunswick, NJ

Macaque Species Susceptibility to Simian Immunodeficiency Virus
Joseph Mankowski, DVM, PhD, DACVP, Johns Hopkins University, Baltimore, MD

Background Infections and Molecular Detection of Etiologic Agents
Keith Mansfield, DVM, DACVP, Novartis Institutes for Biomedical Research, Cambridge, MA

Case Presentations

 

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ASVCP and STP CPIG Combined Pre-Meeting Workshop


(Registration required)

Saturday, October 17
8:00 AM-5:00 PM

Application of New Renal and Hemostatic Biomarkers in Veterinary Medicine and Preclinical Safety: What Can We Learn from Each Other?

Co-chairs: Kirstin Barnhart, DVM, PhD, DACVP, AbbVie, Inc., North Chicago, IL; and Bill Reagan, DVM, PhD, DACVP, Pfizer, Inc., Groton, CT

Boxed lunches will be provided for registered attendees.

Welcome
Kirstin Barnhart, DVM, PhD, DACVP, AbbVie, Inc., North Chicago, IL; and Bill Reagan, DVM, PhD, DACVP, Pfizer, Inc., Groton, CT

Morning Session: Renal Biomarkers
Qualification of New Translational Kidney Safety Biomarkers for Drug Development
Warren Glaab, PhD, Merck, West Point, PA

Recent Developments in Canine Urinary Biomarkers
Mary Nabity, DVM, PhD, DACVP, Texas A&M University, College Station, TX

Assessing Immune Complex Glomerulopathy with Morphology and Biomarkers in Non-human Primate Kidneys during Preclinical Safety Testing of Biologics
Tom P. Brown, DVM, MS, PhD, DACVP, Pfizer, Inc., Lyme, CT

Early Detection of AKI and CKD in Dogs and the Role of IRIS Guidelines
Mary Nabity, DVM, PhD, DACVP, Texas A&M University, College Station, TX

An Integrated Approach to Assessing Kidney Injury
Rachel Cianciolo, DVM, PhD, DACVP, The Ohio State University, Columbus, OH

Afternoon Session: Hemostasis Biomarkers
Hemostasis Gaps in Preclinical and Clinical Studies–Biomarkers for Procoagulant States
A. Eric Schultze, DVM, PhD, FIATP, DACVP, Eli Lilly & Company, Indianapolis, IN

Comparative Hemostasis Testing: Beyond APTT and PT
Marjory Brooks, DVM, DACVIM, Cornell University, Ithaca, New York

Monitoring Hypercoagulability in Pro-thrombotic Conditions and Hypocoagulability in Hemophilic Models, in Non-human Primates
Florence Poitout, DVM, DECVCP, DACVP, Charles River Laboratories, Senneville, Quebec, Canada

Platelet Function Testing in Non-human Primates
Kelly Metcalf Pate, DVM, PhD, DACLAM, Johns Hopkins University, Baltimore, MD

Platelet Isolation Techniques in Laboratory Animals and Platelet Function Testing in Dogs
Adam Aulbach, DVM, DACVP, MPI Research, Mattawan, Michigan

Buccal Mucosal Bleeding Time: Application in Pre-clinical Safety
Kirstin Barnhart, DVM, PhD, DACVP, AbbVie, Inc., North Chicago, IL

 

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C.L. Davis Foundation Pre-Meeting Workshop


(Registration required)

Saturday, October 17
8:00 AM-5:00 PM

The Life Aquatic

Co-Chairs: Jeff Wolf, DVM, DACVP, EPL, Inc., Sterling, VA; and Judy St. Leger, DVM, DACVP, SeaWorld Parks and Entertainment, San Diego, CA

This full-day course will cover topics from normal anatomy and histology to classic and important pathology in aquatic species. Species covered will include fish, amphibians, reptiles, birds, and marine mammals. The tag-team faculty will present material in a step-wise manner so that pathologists will be both engaged and educated. The workshop will focus on the identification of both normal anatomy and common diseases of these species including gross and histologic appearance, salient diagnostic features, and differential diagnosis. This exciting course should be of interest to both clinical and anatomic veterinary pathologists, pathology residents, and diagnosticians working with animals.

 

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NTP Satellite Symposium


(Free event; Registration required)

Saturday, October 17
9:00 AM-4:30 PM

Pathology Potpourri

Chair: Susan A. Elmore, MS, DVM, DACVP, DABT, FIATP, NTP and NIEHS, Research Triangle Park, NC

 

Welcome and Introductory Remarks
Susan A. Elmore, MS, DVM, DABT, FIATP, DACVP, NTP and NIEHS, Research Triangle Park, NC

It's Not a Tumor?
David E. Malarkey DVM, PhD, FIATP, DACVP, NTP, NIEHS, Research Triangle Park, NC

Cardiomyopathy Shuffle 
Rick Hailey, DVM, Covance, Inc., Chantilly, VA

Queries from the Zoo
Patricia A. Pesavento DVM, PhD, DACVP, University of California-Davis, Davis, CA

An Exigent Pancreatic Tumor?
Ramesh C. Kovi, BVSc&AH, MVSc, PhD, DACVP, EPL, Inc., Research Triangle Park, NC

Intracranial Conundrums I
James P. Morrison DVM, DACVP, Charles River Pathology Associates, Durham, NC

Mammary Gland Development: The "Whole" Story
Erin Quist, DVM, MS, DACVP, NTP, NIEHS, Research Triangle Park, NC

Canine and Rodent Pulmonary Pathology: Are They the Same or Different?
Kathleen A. Szabo, DVM, MS, DACVP, Charles River Pathology Associates, Durham, NC

Imprints, Smears, and Preps – Oh My!
Jennifer Neel DVM, DACVP (clinical), North Carolina State University, Raleigh, NC

Neuropathology Texas-Style
Brian F. Porter DVM, DACVP, Texas A&M University, College Station, TX

Intracranial Conundrums II
James P. Morrison DVM, DACVP, Charles River Pathology Associates, Durham, NC

Challenging Cases from the Special Senses INHAND OWG
Cindy A. Farman DVM PhD, DACVP, Genentech, South San Francisco, CA; and Leandro Teixeira DVM MSc, DACVP, University of Wisconsin-Madison, Madison, WI

 

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STP Pre-Meeting CE Course 2


(Registration required)

Saturday, October 17
1:30 PM-5:30 PM

The Use of Pigs in Biomedical Research

Co-Chairs: Lydia Andrews-Jones, DVM, PhD, DACVP, Allergan, Lake Forest, CA; and Kristie Mozzachio, DVM, DACVP, WIL Research, Hillsborough, NC

Swine are increasingly being used in biomedical research, both in toxicologic pathology and in medical devices work, including as possible organ donors for humans. This course will review the various strains of pigs used for biomedical research, their unique anatomy, clinical pathology, and background diseases and lesions. In addition to general toxicology, the use of pigs in dermatologic, ocular, and device work will be reviewed by subject matter experts.

Pig Strains Used in Biomedical Research: Sources, Origins, and Colony Health Management
Guy Bouchard, DVM, MS, DACT, Sinclair Research Center, LLC, Columbia, MO

Pig Anatomic and Clinical Pathology: Background and Unique Considerations
Kristie Mozzachio, DVM, DACVP, WIL Research, Hillsborough, NC

Sexual Maturity of Minipigs
Paul Howroyd, MA, VETMB, MRCVS, FRCPath, WIL Research Europe-Lyon, St Germain sur L'Arbresle, Lyon, France

Pigs in General Toxicology—The European Perspective
Alys Bradley, BSc, BVSc, MAnimSc, DipRCPath, FRIPH, MRCVS, FRCPath, FIATP, Charles River Laboratories, Edinburgh, Scotland, UK

The Minipig as a Translationally Relevant Model of Human Cardiovascular Disease
James Turk, AB, DVM, PhD, DACVP, Amgen, Inc., Thousand Oaks, CA

The Swine as a Model in Experimental and Translational Medicine
Alain Stricker-Krongrad, PhD, MSc, Sinclair Research Center, LLC, Columbia, MO

So... How DO You Work with Pigs?
Kristie Mozzachio, DVM, DACVP, WIL Research, Hillsborough, NC

 

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ACVP/ASVCP/STP Post-Meeting Workshop I


(Registration required)

Wednesday, October 21
1:00 PM-5:00 PM

Case-based Molecular Pathology: State-of-the-Art

Co-Chairs: David Malarkey, DVM, PhD, DACVP, NIEHS, Research Triangle Park, NC; and Gerry O'Sullivan, MVB, MSc, PhD, DECVP, DACVP, University of Minnesota, St. Paul, MN

Overview of Workshop
David Malarkey, DVM, PhD, DACVP, NIEHS, Research Triangle Park, NC; and Gerry O'Sullivan, MVB, MSc, PhD, DECVP, DACVP, University of Minnesota, St. Paul, MN

Case 1: Utility of Clonality Assays in the Diagnosis of Malignant Lymphoma.
Anne Avery, VMD, PhD, Colorado State University, Fort Collins, CO

Case #2: Benefits of Comparative Genomic Hybridization and Chromosomal Abnormalities in Prognosticating Canine Neoplasms
Matthew Breen, PhD, CBiol, FSB, North Carolina State University, Raleigh, NC

Case #3: Molecular Biomarkers in Determining the Prognosis of Canine Mast Cell Tumors
Matti Kiupel, DrVetMed, BS, MS, PhD, DACVP, Michigan State University, Lansing, MI

Case #4: Genomics of Rat Liver Cancer: Origin and Evolution of Hepatoblastomas in the Mouse
Arun Pandiri, BVSc&AH, MS, PhD, DACVP, DABT, EPL, Inc./NTP, Research Triangle Park, NC

Case #5: Predictive Gene Profiling of Liver Toxicants and Carcinogens
Scott S. Auerbach, PhD, DABT, NTP/NIEHS, Research Triangle Park, NC

Case #6: Diagnosis of Porcine Epidemic Diarrhea: Which is the Latest New Important Disease in Swine
Stephanie Rossow, DVM, PhD, University of Minnesota, Minneapolis, MN

Case #7: Fulfilling Koch’s Postulate: The Role of Molecular Biology in Establishing Illnesses Caused By Bartonellosis
Ricardo G. Maggi, MS, PhD, North Carolina State University, Raleigh, NC

Panel Discussion with Workshop Faculty

 

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Post-Meeting Workshop II


(Registration required)

Wednesday, October 21
1:00 PM-5:00 PM

Mouse Central Nervous System Neuropathology 

Co-Chairs: Jerrold M. Ward, DVM, PhD, DACVP, Global Vet Pathology, Montgomery Village, MD; and Caroline Zeiss, BVSc, PhD, DACLAM, DACVP, Yale University, New Haven, CT

Mouse Brain Evaluation: How and Where to Look — An Overview of Mouse Neuroanatomy
Deepa B. Rao, BVSc, MS, PhD, DABT, DACVP, FDA, Silver Spring, MD

An Overview of Mouse Neuropathology: Spontaneous Lesions and Artifacts
Ingrid D. Pardo, DVM, MS, DACVP, Pfizer Inc., Groton, CT

Mouse Brain Tumors: GEM and Preclinical Models
Jerrold M. Ward, DVM, PhD, DACVP, Global Vet Pathology, Montgomery Village, MD

Translational Preclinical CNS Mouse Models I–Discovery
Caroline Zeiss, BVSc, PhD, DACLAM, DACVP, Yale University, New Haven, CT

Translational Preclinical CNS Mouse Models II–Safety
Ingrid D. Pardo, DVM, MS, DACVP, Pfizer Inc., Groton, CT

 

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