Program

STP 40TH ANNUAL SYMPOSIUM PROGRAM

Toxicologic Pathology Relevant to Pediatric Populations

Scientific Co-Chairs: Marie-Odile Benoit-Biancamano, DVM, MSc, DACVP, DECVP, University of Montreal, Montreal, Quebec, Canada; Wendy Halpern, DVM, PhD, DACVP, Genentech, Inc., South San Francisco, CA; George A. Parker, DVM, PhD, DACVP, DABT, Charles River Laboratories, Durham, NC

Continuing Education Chair: Darlene Dixon, DVM, PhD, DACVP, NIEHS/NTP, Research Triangle Park, NC

Continuing Education Co-Chair: Sanjeev Gumber, BVSc, MVSc, PhD, DACVP, Yerkes National Primate Research Center, Emory University, Atlanta, GA

Drugs and environmental chemicals may have effects on pediatric populations that are different from those observed in adult populations. These differences may be a result of heightened, or occasionally reduced, sensitivity based on postnatal morphological, physiological, or biochemical development in the pediatric population. Since safety in adult animals and people does not always translate to safety in children, pediatric safety assessment is needed for xenobiotics with significant pediatric exposures. Approaches to safety assessment are varied depending on context of exposure, as well as specific regulatory requirements or expectations. The overall goal of the 2021 STP Symposium is to provide attendees with background information on the morphological, physiological, and biochemical variations of juvenile animals that are commonly used in safety assessment studies of drugs and chemicals. The Symposium will focus on organs that have a great degree of postnatal development and relationships to specific regulatory agency requirements.