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STP 35th Annual Symposium
General Information Scientific Program Exhibits Hotel & Travel Registration Abstracts Students      

General Information

Scientific Co-Chairs: Darlene Dixon, DVM, PhD, DACVP, NIEHS/NTP, Research Triangle Park, NC; Kathryn E. Gropp, DVM, PhD, DACVP, Pfizer, Inc., Groton, CT; and Armando Irizarry, DVM, PhD, DACVP, Eli Lilly & Company, Indianapolis, IN

Continuing Education Chair: Emily Meseck, DVM, DACVP, DABT, Novartis Pharmaceuticals Corporation, East Hanover, NJ

Continuing Education Co-Chair: Kirstin F. Barnhart, DVM, PhD, DACVP, AbbVie, Inc., North Chicago, IL

The Basis and Relevance of Variation in Toxicologic Responses

Toxicologic responses elicited by chemical, pharmacological, or environmental agents can vary considerably among and within species and studies. Variation in toxicologic responses can confound results, complicate interpretation of data, interfere with reproducibility, and make extrapolation to humans problematic. Many factors can influence or be the source of significant variation in toxicologic responses. The 2016 STP symposium will focus on the basis and relevance of variation in toxicologic responses. Talks will describe key factors that impact the interpretation of nonclinical discovery and development studies. The symposium will kick off with “Real World Toxicology Outcomes: Impact of Species and Strain Selection on Drug Development Programs.” The following sessions will delve deep into topics that influence the accuracy of toxicology translatability to human health, including species and strain differences, animal model selection and disease predictability, genetics and epigenetics, hormones, age, drug metabolism, the microbiome, gene-environment interactions, formulations, study design (including special points to consider when designing developmental and reproductive toxicology studies), and much more. Prominent topics will include variables that influence the interpretation of clinical pathology parameters; the role of emerging technologies (genome-wide epigenetic and transcriptomic profiling) and modern data analyses (bioinformatics); and the impact of genotype-phenotype relationships in selecting the correct animal model, including non-human primates. This symposium will emphasize real-life examples to demonstrate how to identify the underlying causes of variability in nonclinical studies and to provide the background to place this variability into context for translation of animal data sets to human hazard identification and risk assessment.

This program 56-25618 is approved by the AAVSB RACE to offer a total of 20.00 CE Credits (20.00 max) being available to any one veterinarian: and/or 20.00 Veterinary Technician CE Credits (20.00 max). This RACE approval is for the subject matter categorie(s) of: Category One: Scientific using the delivery method(s) of: Seminar/Lecture. This approval is valid in jurisdictions which recognize AAVSB RACE; however, participants are responsible for ascertaining each board's CE requirements

Annual Symposium Overview


Online Registration

Saturday, June 25
Pre-Meeting NTP Symposium: Pathology Potpourri (Free Event, Registration Required)


Sunday, June 26
CE Courses (Half Day, Fee to Attend)

  • The Respiratory System as a Target for Drug-induced Toxicity: Pathology and Investigational Techniques
  • Interpreting and Integrating Clinical and Anatomic Pathology Results: Pulling It All Together
  • Hematotoxicity and Immunotoxicity Assessment: Essential Principles and Emerging Modalities
  • Is it Adverse, Adaptive, Artifact?

Career Development Workshop (AM Half Day)

  • Toxicity Testing in the 21st Century: Will In Vivo Studies Become Obsolete?

Welcome Reception/Exhibits Opening

Monday, June 27
Exhibits and Poster Sessions Open

Symposium Welcome and Keynote Address: Cornerstones of Toxicology

Session 1
(AM): Real World Toxicology Outcomes: Impact of Species and Strain Selection on Drug Development Programs

Career Development Lunchtime Series (Free Event, Registration Required)

  • Interacting with Our MD Colleagues

Session 2 (PM): Deciphering Sources of Variability in Clinical Pathology—It’s Not Just about the Numbers

Exhibitor-Sponsored Lunch for Registered Symposium Attendees
Town Hall Meeting

Tuesday, June 28
Exhibits and Poster Sessions Open

Session 3 (AM): Influence of Experimental Design and Environmental Conditions

Student Outing

Wednesday, June 29
Exhibits and Poster Sessions Open

Session 4A (AM): Influence of Epigenetics, Genetics, and Immunology (Part 1)

Postnatal Organ Development as a Complicating Factor in Juvenile Toxicity Studies
(Free Event, Registration Required)
Sponsored by IATP and STP

Session 4B (PM): Influence of Epigenetics, Genetics, and Immunology (Part 2)

Awards Ceremony
Annual Business Meeting
President’s Reception

Thursday, June 30
Session 5 (AM): Influence of Age, Hormones, and the Microbiome

Meeting Materials

Meeting publications, including final Program, handouts, attendee list, committee, interest group, and ancillary meetings schedules and evaluation forms will be posted on the Meeting Materials page when available.

STP members will use their regular logins to access this page. Nonmember attendees will receive logins and passwords to access this page.

Accessibility for Persons with Disabilities

STP wants to ensure that no individual with a disability is excluded, denied services, segregated or otherwise treated differently than other individuals because of the absence of auxiliary aids and services. If you need any auxiliary aids or services identified in the Americans with Disabilities Act, or any assistance in registering for this meeting, please contact STP Headquarters, 703-438-7508, ext. 1443.

Annual Symposium Policies

Child Attendance Policy

Photography, Videotaping, Recording Policies
Photography of poster presentations is prohibited without the specific consent of the presenter(s)/author(s). Photography of exhibitor booths and/or equipment is prohibited without the specific consent of the exhibitor. Photography, videotaping, or recording of Scientific Sessions or CE Courses is not permitted.


STP wishes to thank its Corporate Sponsors for their generous support of the Society and its activities, which include all events and scientific sessions at the Annual Meeting. Their donations make it possible for STP to continue to offer high quality science at an affordable fee.

2016 Sponsors

Sponsorship Opportunities

Technical Support
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