STP 38th Annual Symposium Program
Scientific Co-Chairs: Deepa Rao, BVSc, MS, PhD, DABT, DACVP, US FDA, Silver Spring, MD; Jack Harkema, DVM, PhD, DACVP, Michigan State University, Okemos, MI; and Jeffrey Wolf, DVM, DACVP, Experimental Pathology Laboratories, Inc., Sterling, VA
Continuing Education Chair: Gopakumar Gopalakrishnan, DVM, MS, DABT, DACVP, Supernus Pharmaceuticals, Rockville, MD
Continuing Education Co-Chair: Kate Hammerman, VMD, PhD, DACVP, Pfizer, Cambridge, MA
ENVIRONMENTAL TOXICOLOGIC PATHOLOGY AND ONE HEALTH
"When asked if I am pessimistic or optimistic about the future, my answer is always the same: if you look at the science about what is happening on earth and aren't pessimistic, you don't understand the data. But if you meet the people who are working to restore this earth and the lives of the poor, and you aren't optimistic, you haven't got a pulse." — Martin Keogh, Hope Beneath Our Feet: Restoring Our Place in the Natural World.
Mention the word "environment," and our brains naturally conjure up pastoral or oceanic settings populated by a plethora of terrestrial and aquatic wildlife. But our environment is also comprised of urban landscapes, agricultural fields, office buildings, factory floors, the insides of our homes, and our internal microbiomes. Whether exposures occur via intentional therapeutic administration or incidental contact, many of the toxic and potentially toxic substances encountered by humans or animals are essentially exogenous; therefore, at its core, the discipline of toxicologic pathology is all fundamentally "environmental." Investigating the complex web of interactions between environmental contaminants, animals, and humans requires a multi-disciplinary approach that integrates veterinary and human toxicologic pathologists and toxicologists with other scientists such as ecologists, wildlife biologists, epidemiologists, plus various additional health care professionals. Such collaborative efforts comprise the heart of the One Health initiative. The six plenary sessions of the 2019 STP Symposium will encompass a wide variety of cutting edge approaches related to the detection, characterization, mechanistic understanding, and regulatory implications of chemical and physical hazards in natural and anthropomorphic ecosystems, and their recognized or potential deleterious consequences for animals and humans. Symposium session themes include: the toxicology and pathology of air pollution; the toxicologic pathology of workplace agents; toxicity assessment paradigms in regulatory pathology; endocrine disruption and reproductive pathology; pathology in ecological research with implications for One Health; and the integration of big data technologies with toxicologic pathology. Presentations will emphasize toxicologic outcomes that involve real-world scenarios and incorporate the latest scientific developments. Examples of the broad range of individual topics include: examination of the relationship between childhood exposure to air pollution and Alzheimer's disease; rapidly progressive pneumoconiosis in Appalachian coal miners; the assessment of cell phone radiation toxicity; intersex and reproductive abnormalities in fish; effects of pollutants at the ecosystem level, ; and the diagnostic applications of pathology artificial intelligence for global health and medicine.